Individual Controlled Substance Registration

2024-2026 Individual Controlled Substance Registrant Renewals are now CLOSED 

New applications must be mailed.
Faxed or emailed applications are not accepted. 

Additional Forms and Information

A Wyoming Controlled Substance Registration is required for all practitioners who prescribe controlled substances in Wyoming. A practitioner must have a valid Wyoming license and prescriptive authority from their own Board (Nursing, Medicine, etc). A practitioner must obtain a Wyoming Controlled Substance Registration to apply for a federal DEA registration. A Wyoming Controlled Substance Registration expires on June 30 and is renewed biennially (every two years).

Issuing and Dispensing Controlled Substances 

As a reminder, pursuant to Wyoming Statute 35-7-1030, controlled substances are required to be electronically prescribed. You may review the Wyoming Controlled Substances Act Rules Chapter 10: Issuing and Dispensing Prescriptions for Controlled Substances for more information.

As a reminder, practitioners, other than veterinarians, are required to search the PDMP pursuant to Wyoming Statute 35-7-1060. Practitioners may appoint delegates to perform searches in the PDMP on their behalf. The PMP AWARxE User Guide contains useful information on setting up user accounts, delegates accounts, managing delegates, reviewing prescriptions for which you were listed as the prescriber, and more.

Dispensers (including practitioners who dispense controlled substances to patients) are required to report dispensing information into the PDMP database. This information must be entered no later than the close of business on the business day immediately following the day the controlled substance was dispensed. For more information please review the Wyoming Controlled Substances Act Rules Chapter 8: Prescription Drug Monitoring Program and the Data Submission Dispenser Guide. Zero reports must be submitted into the PMP Clearinghouse when a dispenser does not have any dispensations to report.


Streamline your workflow. Save Time. Focus on Patient Care. PMP AWARxE Wyoming can now be accessed through approved electronic health records (EHR) and pharmacy management systems (PMS).

The Board is pleased to announce a statewide initiative to integrate PMP AWARxE Wyoming into approved EHR/PMS using Bamboo Health’s PMP Gateway service. The integration will eliminate the need for providers to navigate to the PMP AWARxE Wyoming website, log in, and enter their patient’s information. Instead, the EHR/PMS will automatically initiate a patient query, which will return the patient’s controlled substance prescription records directly within the clinical workflow inside the EHR/PMS. 

It is important to note that not all EHR/PMS vendors are currently integrated. Please submit your integration request anyway, as the status may change as new vendors are regularly integrated. Your integration process and duration time is dependent upon your vendor.

What is the integration request process?

Additional Entities Required to Obtain a Wyoming Controlled Substance Registration:

The following entities are also required to obtain a Wyoming Controlled Substances Registration if they possess, manufacture, distribute, dispense, or conduct research with controlled substances  in Wyoming:

Additional Forms